Etiology model for many vaccination adverse reactions, including SARS-CoV-2 spike vaccines

<abstract><sec> <title>Objective</title> <p>Vaccinated individuals (vaccinees) experience no adverse events, mild multiple or serious events post vaccination. Many of these vaccine occur with different vaccines occurrence frequencies. are generally considered as associated immune responses to the active components (antigens) and/or possibly one more excipients. Most self-limiting and resolve within days. The number reactions is higher for SARS-CoV-2 spike than all other vaccines. Can data analysis provide etiology insights high reactogenicity vaccines?</p> </sec><sec> <title>Methods</title> <p>The Vaccine Adverse Event Reporting System (VAERS) database was mined by vaccine, age, gender, dose, day onset Results highest were compared.</p> <title>Results</title> <p>For numbers reports, approximates a power two decay pattern first three consistency this unrelated narrows possible mechanisms. event symptoms overlap elevated histamine levels. Herein, innate specifically levels proposed be causative majority events. This hypothesis based on model releasing surge inflammatory molecules, including histamine; hypothesized exceed normal tolerance level vaccinees causing Further, fall below vaccinee's threshold. can evaluated detection in corresponding timing onset. If confirmed, direct consequence predicts that specific antihistamine treatments, mast cell stabilizers, diamine oxidase enzyme may reduce incidence severity experienced vaccinations most coronavirus disease 2019 (COVID-19) vaccines.</p> <title>Conclusions</title> reported occurrences consistent likely result from temporarily exceeds level.</p> </sec></abstract>